Drug name: Brand Nizoral shampoo

Active substance: ketoconazole

Pharmacological effects: Nizoral shampoo is an antimycotic preparation that possesses an antifungal activity against dermatophytes such as Trichophyton sp., Epidermophyton sp., Microsporum sp and yeast fungi like Candida and Malassezia furfur (Pityrosporum ovale). Anti-fungal effects are caused by the increasing the permeability of the fungall cells wall. This makes fungal cells unviable. Nizoral shampoo lowers exfolation and itching associated with dandruff, seborrheic eczema, scaly skin disease.

Indications: Nizoral shampoo is approved for treatment and prophylaxis of skin diseases caused by yest fungi Malassezia furfur (Pityrosporum ovale): dandruff, seborrheic eczema, scaly skin disease.

Warnings and Precautions: The drug should not be used in the following conditions:

• Hypersensitivity to any components of the preparations.

Nizoral shampoo is only for external use.

• You should avoid getting the Nizoral shampoo in the eyes. If shampoo enters the eyes, rinse immediately with plenty of water.

Nizoral shampoo can be used during pregnancy and breastfeeding

Nizoral shampoo side effects: Drugs may cause side effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of Nizoral that were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Nizoral shampoo is usually well tolerated.

• In rare cases Nizoral side effects include: local irritation, itching, contact dermatitis, hair fatness and dryness.

For full information on any risks and adverse effects associated with Nizoral, please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Nizoral shampoo please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of Nizoral shampoo therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

• Nizoral shampoo is not absorbed into the bloodcirculation and ,thus can not interact with other medications

Patients information: Nizoral shampoo is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the course of treatment should be kept out of reach of children and never reused.