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Pharmacological effects:

Advair Diskus is a glucocorticosteroid with anti-inflammatory, antiallergic, and antipruritic properties. Its active substance, Fluticasone Propionate, inhibits proliferation of mast cells, eosinophils, lymphocytes, macrophages and neutrophils, reduces production and release of inflammatory mediators and other biologically active substances (histamine, eicosanoids, leukotrienes and cytokines).

In therapeutic doses, the drug has almost no effect on the hypothalamic-pituitary-adrenal system.

Indications:

Anti-inflammatory therapy of

• bronchial asthma
• chronic obstructive pulmonary disease (including chronic bronchitis and emphysema)

Warnings and Precautions: The drugs should not be used in the following conditions:

• hypersensitivity to any components of the preparations.
• pregnancy, breastfeeding
• children aged below 4

Use with caution in:

• pulmonary tuberculosis

Side effects: Drugs may cause side-effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of Fluticasone Propionate that were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Advair Diskus side effects include:

• candidiasis of oral cavity and throat
• hoarseness
• paradoxical bronchospasm
• prolonged use at high doses, concomitant or previous use of oral corticosteroids in rare cases may cause adrenal dysfunction, osteoporosis, growth retardation in children, cataracts, glaucoma

For full information on any risks and adverse effects associated with Fluticasone Propionate, please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Advair Diskus please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of Fluticasone Propionate therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

• inhibitors of the enzyme CYP3A4

Patients information: Advair Diskus is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the course of treatment should be kept out of reach of children and never reused.