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Pharmacological effects:

Generic Pulmicort is an antiasthmatic drug; a glucocorticosteroid (GCS) for inhalation use. Its active substance, budesonide, has anti-inflammatory, antiallergic and antiexudative properties. Budesonide has no mineralocorticosteroid activity.

Anti-inflammatory effect of Generic Pulmicort is mediated by reduction of airway obstruction during early and late allergic response. Pulmicort has an inhibitory effect on the release of allergic inflammation mediators and cytokine-mediated immune response. The drug reduces the severity of edema of the bronchial mucosa, mucus production, development of sputum and airway hyperresponsiveness. Reduces airway reactivity in response to inhaled histamine and methacholine. It reduces airway reactivity in response to inhaled histamine and methacholine.

Indications:

• bronchial asthma requiring glucocorticosteroids maintenance therapy
• chronic obstructive pulmonary disease

Warnings and Precautions: The drugs should not be used in the following conditions:

• hypersensitivity to any components of the preparations.
• children

Pulmicort should be used with caution in case of:

• pregnancy, breastfeeding
• active or inactive form of pulmonary tuberculosis
• fungal, viral or bacterial infections of the respiratory system
• liver cirrhosis

Side effects: Drugs may cause side-effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of budesonide that were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Generic Pulmicort side effects include:

• oropharyngeal candidiasis, throat irritation, cough, hoarseness, dry mouth
• rash, urticaria, angioedema, contact dermatitis, bruising of the skin
• nervousness, irritability, depression, behavioral disorders
• symptoms caused by the systemic action of glucocorticosteroids

For full information on any risks and adverse effects associated with budesonide, please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Generic Pulmicort please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of budesonide therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

• antimycotics
• potential inhibitors of CYP3A4
• methandrostenolone
• estrogens

Patients information: Generic Pulmicort is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the course of treatment should be kept out of reach of children and never reused.