Drug name: Brand Logest

Active substance: Ethinyl estradiol, Gestodene

Pharmacological effects: Logest is a combined preparation the effect of which is associated with the active ingredients included in the drug. The contraceptive effect of the preparation is achieved due to the following therapeutic mechanisms:

• Prevention of ovule formation
• Decreased responsiveness of the endometrium to the embryonic sac
• Increased viscosity of the cervical mucous

Logest also exerts specific beneficial effects:

• Normalization of the menstrual cycle
• Prevents certain gynecological disease including tumor formation

Indications: The drug is indicated as a contraceptive but also may be used after a thorough consultation with your health care provider for treatment of functional changes in the menstrual cycle.

Warnings and Precautions: The drugs should not be used in the following conditions:

• Hypersensitivity to any components of the preparations.
• Liver failure
• Liver tumors
• Thromboembolia
• Inborn hyperbilirubinemia
• Cerebral blood flow dysfunctions
• Ischemic heart disease
• Arterial hypertension
• Atherosclerosis
• Myocarditis
• Diabetes
• Retinopathy
• Angiopathia
• Cardiac malformation
• Anemia
• Hormone dependent cancer of the mammary gland or of the endometrium
• Lipid metabolism dysfunctions
• Idiopathic jaundice, skin itching before pregnancy
• Inflammatory disease of the womens urogenital tract
• Otosclerosis
• Epilepsy
• Porphyry
• Pregnancy
• Lactation period
• Patients after 35 years of age
• Predisposition to uterine bleeding
• Hyperfollicular climax stage

Side effects: Drugs may cause side-effects which in specific patients may manifest differently. In the following paragraph we want to underline the most serious and frequent side effect of Logest that were identified by the drug manufacturers. The possibility of the adverse effect manifestation depends only on the individual and his specific traits. Logest side effects include:

• Gastro-intestinal tract: gastralgia, nausea, vomiting, jaundice, hepatocellular adenoma
• Endocrine system: breast engorgement, increased body weight, decreased libido, polymenorrhea
• CNS: headache, mood changes
• Cardiovascular system: thrombophlebitis, thromboembolia
• Sensory organs: vision impairment, decreased hearing
• Allergic reactions
• Others: generalized itching, bleeding, chloasma, Na+ and Ca2+ metabolism changes

For full information on any risks and adverse effects associated with Logest , please consult your doctor, read the included leaflet or contact our customer support service.

Interactions: Before using Logest please tell your doctor which drugs or supplements you are already taking including those bought without a prescription. Also check if any additional medicine which you will take during the course of Logest therapy are safe in combination. Especially mention if you are taking the following groups of drugs:

• Antiepileptics
• Steroid hormones
• Antibiotics
• Diabetes treatment

Patients information: Logest is not to be shared with healthy individuals. It is strictly FORBIDDEN to use the drugs in treatment of any conditions unrelated to their indications. The product as well as utilized vials, syringes, needles if used during the course of treatment should be kept out of reach of children and never reused.