The technology of ultra-filtration allows to exclude the presence of protein components with antigenic and pyrogenic properties as well as the presence of infectious agents.

Actovegin contains only natural physiological components such as amino acids, electrolytes (Mg, Na, Ca, P, K ),oligopeptides, nucleosides, intermediary products from fat and carbohydrare metabolism. One of the main physiologically active component in Actovegin is inositol phospho-oligosaccharides.

Actovegin contains only low molecular weight organic compounds which are below 5000 daltons.

According to its pharmacological effects, Actovegin can be attributed to the group antihypoxants and antioxidants. Anti-hypoxic action is associated with increasing the consumption of oxygen by the tissues and decreasing the demand in oxygen by the cellular structure. Actovegin also helps increase the resistance of cellular structures to hypoxia. This it its turn increases the formation of high-energy phosphates in cellular structural and leads to activation of oxidative phosphorylation enzymes. Actovegin stimulates carbohydrate and proteins synthesis and disintegration of anaerobic glycolysis. The improvement of blood flow in the microcirculatory system under the action of Actovegin is associated with normalization of endothelium-dependent reactions (vasodilatation) and decreasing peripheral vascular resistance.

Moreover, free-protein extract of calf bloods stimulates endothelial production of natural anticoagulants and antiplatelet agents that significantly helps reduce the risk of wall thrombosis.

Antioxidant effect of Actovegin is associated with the substances called superoxide dismutase as well as magnesium ions which increase the activity of glutathione synthetase. Another pharmacological effect of Actovegin consists in improving the transport of glucose in the cells due to activation of its transporters (GluT) (via increasing of oligosacharides). The action of Actovegin is insulin-independent which is clinically significant for patients with insulin-resistance.

The results of numerous studies show that Actovegin modulates the activity of intracellular glucose transport leading to intensification of lypolysis. It intensifies the speed of oxidative-restorative processes in hepatocytes, decreases ultra-structural and functional damages of mitochondria in cardiomyocytes, increases the decreased level of glucose metabolism in patients with chronic alcoholism.

Actovegin is recommended for widespread use in different branches of medicine. It is actively indicated for the prophylaxis of reperfusion in patients with heart attacks, in the treatment of different shocks, after circulatory arrest and asphyxia, in severe heart failure.

Currently, Actovegin is actively used for the treatment of cerebrovascular diseases and cognitive disorders of different severity. The preparation significantly improves mnestic functions, attention and brain work.